Mitoxantrone-Surfactant Interactions: A Physicochemical Overview

Mitoxantrone-Surfactant Interactions: A Physicochemical Overview.

Mitoxantrone is a synthetic anticancer drug used clinically in the treatment of different types of cancer. It was developed as a doxorubicin analogue in a program to find drugs with improved antitumor activity and decreased cardiotoxicity compared with the anthracyclines. As the cell membrane is the first barrier encountered by anticancer drugs before reaching the DNA sites inside the cells and...

Physicochemical properties of surfactant lipids.

brane disease which is a major CauSe Of death Of newborn (premature) infants. However, there are other pathological Appi. physiol. 42,483-491 lung conditions connected with surfactant. Adult respiratory distress syndrome (Lachmann, 1983), alveolar lipoChemosphere 13, 101-105 proteinosis (Claypool et al., 1984), and acute pancreatitis (Idegami et al., 1983) are examples of such conditions. Vario...

Membrane-Surfactant Interactions

Complex I11 (ubiquinol-cytochrome c reductase) was purified from beef heart mitochondria in the form of protein-phospholipid-Triton X100 mixed micelles (about 1:SO:lOO molar ratio). Detergent may be totally removed by sucrose density gradient centrifugation, and the resulting lipoprotein complexes retain full enzyme activity. In order to understand the role of surfactant in the mixed micelles, ...

Polymer–surfactant Interactions

Surfactants and polymers are two of the important components in detergent formulations. The interactions between polymers and surfactants in aqueous media give rise to the formation of association structures, thereby modifying the solution and interfacial properties. The morphologies of association complexes depend on the molecular properties of the polymer and the surfactant. In this paper, we...

Biopolymer Surfactant Interactions